Endocrine Abstracts

Introduction: Klinefelter syndrome patients (KS) frequently show low bone mass, which could have multiple aetiologies. The structural basis of low bone mass and its consequences on bone strength are almost not known, but analogies in bone microstructure and strength between KS and ageing women have proposed by studying distal tibia by HRpQCT. The aim of this study was to compare proximal femur strength and bone structure of KS with elderly women and men....

PTH promotes conversion of 25-hydroxyvitamin D (25[OH]D) to 1,25-dihydroxyvitamin D (1,25[OH]2D), thus stimulating intestinal calcium and phosphate absorption. Because of low PTH levels in hypoparathyroidism, patients are prescribed calcitriol. Patients are predisposed to hyperphosphatemia owing to loss of PTH-stimulated phosphate excretion by the kidneys. Effects of rhPTH(1–84) on vitamin D metabolism and serum phosphate were studied.In ...

Introduction: Chromogranin A (CgA) is a major representative of the protein family named granins stored predominately in secretory granules of the diffuse neuroendocrine system. Circulating CgA serves as a biomarker of neuroendocrine tumors (NETs), but its increased plasma concentration is present in various cardiovascular, gastrointestinal, renal and inflammatory diseases. Intra-granular and/or extracellular proteolysis of CgA generates a variety of biologically active fragme...

Background: In severe obesity, hypogonadism in men and androgen excess in women are frequently observed. Sex hormones play an important role in body composition, glucose and lipid metabolism. Bariatric surgery is the most effective treatment strategy to combat morbid obesity. However, if preoperative gonadal dysfunction impacts weight loss and metabolic improvements after surgery is not known.Methods: 49 men and 104 women were included in a retrospective...

Background: Patients being cured of craniopharyngioma (CP) often suffer from severe hypothalamic obesity due to tumor localization or therapeutic interventions, which has a major impact on increased mortality and reduced quality of life. Gastric bypass surgery (GBS) was suggested to be an effective therapeutic option for weight reduction in those patients. However, long-term changes in body weight and postsurgical complications are unknown.Methods: 5 pat...

The aim of this research was foot mineralization level definition by means of the two-absorbing X-ray densitometer and marking out group of the greater risk of a foot mineralization disorder development at patients with diabetes.Materials and methods: Decrease in a foot mineralization at diabetes patients conformed a mineralization of metatarsal bones below 0.50 g/cm2 level and (or) tarsal bones below 0.69 g/cm2 level.<p class="...

Cushing’s disease is relatively rare and affects most commonly adults aged 20 to 40. It is associated with high morbidity and mortality; early detection and diagnosis of Cushing’s disease may lead to decreased this two facts and improved quality of life.We present a 32-year-old man with abdominal purple striae, central obesity with typical ‘moon face’ and oscillatory blood pressure values.Hormonal exams revealed...

Introduction: Tendency to store lipids centrally is well connected to development of diabetes mellitus type 2 (T2DM) and cardiovascular morbidity. Providing insight in this process is important.Method: Relationship between radius of waist line and thickness of subcutaneous adipose tissue (SAT) was compared among forty obese patients (BMI> 30 kg/m2) in the light of their glycemic control parameters (fasting glucose, HOMA IR, HOMA beta).Pati...

Introduction: Hormonal syndromes are significant cause of morbidity in patients with neuroendocrine tumors (NET), requiring special treatment, rarely completely efficient. Effect on mortality is also presumed. Our aim was to investigate epidemiological characteristics of NET with hormonal production in our group of patients.Patients and methods: We analyzed 822 patients with NET of various primary tumor sites, treated at our department during period of 2...

IntroductionHypogonadism is a potential manifestation of many chronic diseases including cancer, presumably related to their severity. Since novel anti-cancer treatments have significantly increased survival rates of affected patients, issue of hypogonadism becomes more significant, given the importance of issues like quality of life and potential for reproduction. The aim of our study was to analyze gonadal axis function in male patients with neuroendoc...